This paper presents new results from the ongoing study of the unusual Lynx-Cancer void galaxy DDO 68, which has star-forming regions of record low metallicity [12+log (O/H) ∼7.14]. The results include the following. (i) A new spectrum and photometry have been obtained with the 6-m SAO RAS telescope (BTA) for the luminous blue variable (LBV = DDO68-V1). Photometric data sets were complemented with others based on the Sloan Digital Sky Survey (SDSS) and the Hubble Space Telescope (HST) archive images. (ii) We performed an analysis of the DDO 68 supergiant shell (SGS) and the prominent smaller Hα arcs/shells visible in the HST image coupled with kinematic maps in Hα obtained with the Fabry-Perot interferometer (FPI) at the BTA. (iii) We compiled a list of about 50 of the most luminous stars (-9.1 mag < MV < -6.0 mag) identified from the HST images associated with the star-forming regions with known extremely low O/H. This is intended to pave the path for the current science to be investigated with the next generation of giant telescopes. We have confirmed earlier hints of significant variation of the LBV optical light, deriving its amplitude as ΔV >= 3.7 mag for the first time. New data suggest that in 2008-2010 the LBV reached MV = -10.5 mag and probably underwent a giant eruption. We argue that the structure of star-forming complexes along the SGS ('Northern Ring') perimeter provides evidence for sequential induced star-formation episodes caused by the shell gas instabilities and gravitational collapse. The variability of some luminous extremely metal-poor stars in DDO 68 can currently be monitored with medium-size telescopes at sites with superb seeing.